Rapid screening method for new psychoactive substances of forensic interest: electrochemistry and analytical determination of phenethylamines derivatives (NBOMe) via cyclic and differential pulse voltammetry

Andrade, Ana Flávia B., Mamo, Samuel Kasahun and Gonzalez-Rodriguez, Jose (2017) Rapid screening method for new psychoactive substances of forensic interest: electrochemistry and analytical determination of phenethylamines derivatives (NBOMe) via cyclic and differential pulse voltammetry. Analytical Chemistry, 89 (3). pp. 1445-1452. ISSN 0003-2700

Full content URL: http://doi.org/10.1021/acs.analchem.6b02426

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Rapid screening method for new psychoactive substances of forensic interest: electrochemistry and analytical determination of phenethylamines derivatives (NBOMe) via cyclic and differential pulse voltammetry

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Rapid screening method for new psychoactive substances of forensic interest: electrochemistry and analytical determination of phenethylamines derivatives (NBOMe) via cyclic and differential pulse voltammetry
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Abstract

The NBOMe derivatives are phenethylamines derived from the 2C class of hallucinogens. Only a few human pharmacologic
studies have been conducted on these drugs and several cases of intoxication and deaths have been reported. Presently,
NBOMe are not a part of the routine drugs-of-abuse screening procedure for many police forces and there are no rapid immunoassay
screening tests that can detect the presence of those compounds. In this paper, the voltammetric behavior of 25B NBOMe and
25I NBOMe were investigated and their electroanalytical characteristics determined for the first time. A novel, fast and sensitive
screening method for the identification of the two most common NBOMes (25B-NBOMe and 25I-NBOMe) in real samples is
reported. The method uses the electrochemical oxidation of these molecules to produce an analytical signal that can be related to the
NBOMe concentration with an average lower limit of quantitation of 0.01mg/mL for both of them. The method is selective enough
to identify the two compounds individually, even given the great similarity in their structure.

Keywords:Chemistry, NotOAChecked
Subjects:F Physical Sciences > F180 Analytical Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:25805
Deposited On:12 Jan 2017 17:47

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