Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

Hanauer, Thomas, Hopkinson, Richard J, Patel, Kamel, Li, Yu, Correddu, Danilo, Kawamura, Akane, Sarojini, Vijay, Leung, Ivanhoe K. H. and Gruber, Tobias (2017) Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor. Organic & Biomolecular Chemistry, 15 . pp. 1100-1105. ISSN 1477-0520

Documents
__network.uni_staff_S3_tgruber_Hanauer_OBC_Calixarene_lysine_OBC_resub_final.pdf
[img]
[Download]
[img]
Preview
PDF
__network.uni_staff_S3_tgruber_Hanauer_OBC_Calixarene_lysine_OBC_resub_final.pdf - Whole Document

605kB
Item Type:Article
Item Status:Live Archive

Abstract

Chemical tools that recognise post-translational modifications
have promising applications in biochemistry and in therapy. We
report a simple carboxycalixarene that selectively binds molecules
containing di/trimethylammonium moieties in isolation, in cell
lysates and when incorporated in histone peptides. Our findings
reveal the potential of using carboxycalixarene-based receptors to
study epigenetic regulation.

Keywords:Calix[4]arene, calixarene
Subjects:F Physical Sciences > F160 Organic Chemistry
C Biological Sciences > C720 Biological Chemistry
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Pharmacy
Related URLs:
ID Code:25804
Deposited On:19 Jan 2017 21:10

Repository Staff Only: item control page