Magnetic resonance imaging assessment of a convective therapy delivery paradigm in a canine prostate model

Shetty, Anil M., Stafford, R. Jason, Elliott, Andrew M., Kassouf, Kassouf, Brown, Gordon A., Stephens, Clifton, Tinkey, Peggy T., Bidaut, Luc, Pisters, Louis L. and Haz, John D. (2007) Magnetic resonance imaging assessment of a convective therapy delivery paradigm in a canine prostate model. Journal of Magnetic Resonance Imaging, 26 (6). pp. 1672-1677. ISSN 1053-1807

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Item Type:Article
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Abstract

Purpose: To quantitatively investigate the feasibility of MRI as a tool for assessing the spatial distribution of a convectively delivered agent using a canine prostate model. Materials and Methods: Canine prostates (ex vivo, n = 3; in vivo, n = 12) were injected under several injection paradigms with a solution of gadolinium-DTPA for MR contrast and methylene blue as a grossly visible surrogate drug marker. Ex vivo and in vivo distributions were assessed at 1.5T and quantitatively compared. Results: Measured distributions using MRI and methylene blue pathology photographs were analyzed using a Bland-Altman method. The fractional percentage volume covered (Vfrac) compared the measurements grossly: Pearson's correlation coefficients were R = 0.99 for ex vivo and R = 0.77 for in vivo (P < 0.05). The fractional percentage of area covered (Afrac) demonstrated the high degree of spatial correlation between individual slices: R = 0.93 for ex vivo and R = 0.98 for in vivo (P < 0.05). There was no statistically observable bias in scale or offset between the measurements. Conclusion: Measured distributions using MRI and pathology were highly correlated and unbiased, indicating the potential of MRI as a tool for quantitative assessment of interstitial delivery of injected therapies in vivo. © 2007 Wiley-Liss, Inc.

Keywords:gadolinium pentetate, methylene blue, animal experiment, article, controlled study, correlation coefficient, dog, drug distribution, male, nonhuman, nuclear magnetic resonance imaging, priority journal, prostate, rating scale, statistical significance, thermodynamics, Animals, Contrast Media, Dogs, Drug Delivery Systems, Feasibility Studies, Gadolinium DTPA, Injections, Linear Models, Magnetic Resonance Imaging, Methylene Blue
Subjects:F Physical Sciences > F350 Medical Physics
Divisions:College of Science > School of Computer Science
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ID Code:24147
Deposited On:19 Oct 2016 10:20

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