Transrectal quantitative shear wave elastography in the detection and characterisation of prostate cancer

Ahmad, Sarfraz, Cao, Rui, Varghese, Tomy, Bidaut, Luc and Nabi, Ghulam (2013) Transrectal quantitative shear wave elastography in the detection and characterisation of prostate cancer. Surgical Endoscopy, 27 (9). pp. 3280-3287. ISSN 0930-2794

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Item Type:Article
Item Status:Live Archive

Abstract

Background: Shear wave imaging (SWI) is a new ultrasound technique whose application facilitates quantitative tissue elasticity assessment during transrectal ultrasound biopsies of the prostate gland. The aim of this study was to determine whether SWI quantitative data can differentiate between benign and malignant areas within prostate glands in men suspected of prostate cancer (PCa). Methods: We conducted a protocol-based, prospective, prebiopsy quantitative SWI of prostate glands in 50 unscreened men suspected of prostate cancer between July 2011 and May 2012. The ultrasound image of whole prostate gland was arbitrarily divided into 12 zones for sampling biopsies, as is carried out in routine clinical practice. Each region was imaged by grey scale and SWI imaging techniques. Each region was further biopsied irrespective of findings of grey scale or SWI on ultrasound. Additional biopsies were taken if SWI abnormal area was felt to be outside of these 12 zones. Quantitative assessment of SWI abnormal areas was obtained in kilopascals (kPa) from abnormal regions shown by SWI and compared with histopathology. Sensitivity, specificity, positive and negative predictive values, and likelihood ratios were calculated for SWI (histopathology was a reference standard). Results: Fifty patients, with a mean age of 69 ± 6.2 years, were recruited into the study. Thirty-three (66 ) patients were diagnosed with PCa, while an additional 4 (8 ) had atypia in at least one of the 12 prostate biopsies. Thirteen (26 ) patients had a benign biopsy. Data analysed per core for SWI findings showed that for patients with PSA <20 μg/L, the sensitivity and specificity of SWI for PCa detection were 0.9 and 0.88, respectively, while in patients with PSA >20 μg/L, the sensitivity and specificity were 0.93 and 0.93, respectively. In addition, PCa had significantly higher stiffness values compared to benign tissues (p <0.05), with a trend toward stiffness differences in different Gleason grades. Conclusion: SWI provides quantitative assessment of the prostatic tissues and, in our preliminary observation, provides better diagnostic accuracy than grey-scale ultrasound imaging. © 2013 Springer Science+Business Media New York.

Keywords:prostate specific antigen, aged, article, cancer classification, cancer diagnosis, clinical article, clinical practice, clinical protocol, controlled clinical trial, controlled study, diagnostic accuracy, diagnostic test accuracy study, elastography, false positive result, feasibility study, Gleason score, histopathology, human, human tissue, male, mathematical analysis, muscle rigidity, predictive value, priority journal, prospective study, prostate, prostate biopsy, prostate cancer, quantitative analysis, reliability, sensitivity and specificity, shear wave elastography, ultrasound scanner, Young modulus, Adult, Aged, Biopsy, Elasticity Imaging Techniques, Humans, Middle Aged, Predictive Value of Tests, Prospective Studies, Prostatic Neoplasms, Rectum
Subjects:F Physical Sciences > F350 Medical Physics
Divisions:College of Science > School of Computer Science
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ID Code:24121
Deposited On:25 Oct 2016 08:52

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