Stabilisation of metastable polymorphs: the case of paracetamol form III

Telford, Richard, Seaton, Colin C., Clout, Alexander , Buanz, Asma, Gaisford, Simon, Williams, Gareth R., Prior, Timothy J., Okoye, Chidera H., Munshi, Tasnim and Scowen, Ian J. (2016) Stabilisation of metastable polymorphs: the case of paracetamol form III. Chem. Commun., 52 (81). pp. 12028-12031. ISSN 1359-7345

Full content URL: http://dx.doi.org/10.1039/c6cc05006a

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Abstract

The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.

Additional Information:This article is part of themed collection: Pharmaceutical Solids
Keywords:Pharmaceutical solids, JCOpen
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
ID Code:23720
Deposited On:11 Aug 2016 09:23

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