Recognition and Sensing of Creatinine

Guinovart, Tomàs, Hernández-Alonso, Daniel, Adriaenssens, Louis , Blondeau, Pascal, Martínez-Belmonte, Marta, Rius, F. Xavier, Andrade, Francisco J. and Ballester, Pablo (2016) Recognition and Sensing of Creatinine. Angewandte Chemie International Edition, 55 (7). pp. 2435-2440. ISSN 1433-7851

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Item Type:Article
Item Status:Live Archive

Abstract

Current methods for creatinine quantification suffer from significant drawbacks when aiming to combine accuracy, simplicity, and affordability. Here, an unprecedented synthetic receptor, an aryl-substituted calix[4]pyrrole with a monophosphonate bridge, is reported that displays remarkable affinity for creatinine and the creatininium cation. The receptor works by including the guest in its deep and polar aromatic cavity and establishing directional interactions in three dimensions. When incorporated into a suitable polymeric membrane, this molecule acts as an ionophore. A highly sensitive and selective potentiometric sensor suitable for the determination of creatinine levels in biological fluids, such as urine or plasma, in an accurate, fast, simple, and cost-effective way has thus been developed.

Keywords:Chemistry, NotOAChecked
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:22749
Deposited On:24 Mar 2016 09:40

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