Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

Hunt, K. A., Smyth, D. J., Balschun, T., Ban, M., Mistry, V., Ahmed, T., Barrett, J. C., Bhaw-Rosun, L., Bockett, N. A., Brand, O. J., Brouwer, E., Concannon, P., Cooper, J. D., Dias, K-R. M., van Diemen, C. C., Dubois, P.C., Edkins, S., Fölster-Holst, R., Fransen, K., Glass, D. N., Heap, G. A. R., Hofmann, S., Huizinga, T. W. J., Hunt, S., Langford, C., Lee, J., Mansfield, J., Giovanna Marrosu, M., Mathew, C. G., Mein, C.A., Müller-Quernheim, J., Nutland, S., Onengut-Gumuscu, S., Ouwehand, W., Pearce, K., Prescott, N., Posthumus, M. D., Potter, S., Rosati, G., Sambrook, J., Satsangi, J., Schreiber, S., Shtir, C., Simmonds, M. J., Sudman, M., Thompson, S. D., Toes, R., Trynka, G., Vyse, T. J., Walker, N. M., Weidinger, S., Zhernakova, A., Zoledziewska, M., Weersma, R.K., Gough, S.C.L., Sawcer, S., Wijmenga, C., Parkes, M., Cucca, F., Franke, A., Deloukas, P., Rich, S. S., Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

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Keywords:acetylesterase, sialic acid acetylesterase, unclassified drug, autoimmune disease, controlled study, enzyme activity, Europe, gene, gene frequency, genetic association, genetic predisposition, genetic risk, genetic variability, genotype, heritability, homozygote, human, letter, loss of function mutation, major clinical study, priority journal, SIAE gene, single nucleotide polymorphism, Acetylesterase, Autoimmune Diseases, European Continental Ancestry Group, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Variation, Humans, Risk Factors
Subjects:C Biological Sciences > C420 Human Genetics
Divisions:College of Science > School of Life Sciences
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ID Code:22603
Deposited On:19 Mar 2016 22:48

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