The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells

Turyanska, L., Bradshaw, T. D., Li, M. , Bardelang, P., Drewe, W. C., Fay, M. W., Mann, S., Patane, A. and Thomas, N. R. (2012) The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells. Journal of Materials Chemistry, 22 (2). pp. 660-665. ISSN 0959-9428

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Abstract

We report the effects induced by near-infrared apoferritin-PbS (AFt-PbS) nanocomposites on cell cycle progression in non-tumorigenic and cancerous human cells. By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigenic cells is not altered by exposure to AFt-PbS nanoparticles at concentrations up to 1 mg mL -1. In contrast, exposure of human-derived breast cancer cell lines to AFt-PbS at concentrations > 0.2 mg mL -1 triggers apoptotic cell death. The selective death of cancerous cells and the near-infrared fluorescence properties of AFt-PbS could be exploited in both nanomedicine and in vivo imaging studies. © 2012 The Royal Society of Chemistry.

Keywords:Annexins, Apoptotic cell death, Breast cancer cells, Cancerous cells, Cell cycle, Cell-cycle progression, Differential effect, Human cells, In-Vivo imaging, Near Infrared, Near-infrared fluorescence, Cell culture, Cell death, Flow cytometry, Infrared devices, Medical nanotechnology, Vanadium, Nanocomposites
Subjects:B Subjects allied to Medicine > B230 Pharmacy
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:22518
Deposited On:27 Mar 2016 15:09

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