Freeman, Colin, Cheallaigh, Aisling Ni, Singh, Ishwar et al and Heaney, Frances
(2015)
Isoxazole linked oligonucleotide conjugates by on resin and previously clicked nitrile oxide alkyne cycloadditions.
Collection of Czechoslovak Chemical Communications, 12
.
p. 333.
ISSN 0010-0765
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Abstract
Bioconjugation protocols in environments free from residual copper or other catalytic
components are important for therapeutic and biomedical applications as well as in living
systems. In this communication we discuss the versatility of the catalyst free, isoxazole
generating nitrile oxide alkyne Huisgen cycloaddition for provision of chemically modified
oligonucleotide conjugates. Two distinct approaches will be demonstrated. In the first we
discuss on resin cylcoaddition between in situ generated nitrile oxides
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