Impact of mixed solvent on co-crystal solubility, ternary phase diagram and crystallisation scale up

Munshi, Tasnim, Redha, Batul, Feeder, Neil , Meenan, Paul and Blagden, Nicholas (2016) Impact of mixed solvent on co-crystal solubility, ternary phase diagram and crystallisation scale up. Crystal Growth & Design . ISSN 1528-7483

Documents
22445 proof_Crystal Growth and Design.pdf
[img]
[Download]
[img]
Preview
PDF
22445 proof_Crystal Growth and Design.pdf - Whole Document

1MB
Item Type:Article
Item Status:Live Archive

Abstract

This contribution covers the identification, understanding, and rationale of the interplay between the choice of mixed solvent on the crystallization of the co-crystal system benzoic acid and isonicotinamide (BZ:INA). A critical first step was gauging the impact of solvent choice and composition on the overall crystallization process, across a number of temperature points. This required defining the solubility and phase diagrams of the co-crystal system at specified temperatures, which reflects the cooling by crystallization profile encountered in a batch crystallization step. To this end,
identifying and understanding the impact of solvent composition over a selected temperature range on the solubility of co-crystal underpins this contribution.

Keywords:Crystallography, NotOAChecked
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
Related URLs:
ID Code:22445
Deposited On:07 Mar 2016 19:01

Repository Staff Only: item control page