Analysis of the early immune response to infection by infectious bursal disease virus in chickens differing in their resistance to the disease

Smith, Jacqueline, Sadeyenb, Jean-Remy, Butter, Colin , Kaiser, Pete and Burt, David W. (2015) Analysis of the early immune response to infection by infectious bursal disease virus in chickens differing in their resistance to the disease. Journal of Virology, 89 (5). pp. 2469-2482. ISSN 0022-538X

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Abstract

Chicken whole-genome gene expression arrays were used to analyze the host response to infection by infectious bursal disease virus (IBDV). Spleen and bursal tissue were examined from control and infected birds at 2, 3, and 4 days postinfection from two lines that differ in their resistance to IBDV infection. The host response was evaluated over this period, and differences between susceptible and resistant chicken lines were examined. Antiviral genes, including IFNA, IFNG, MX1, IFITM1, IFITM3, and IFITM5, were upregulated in response to infection. Evaluation of this gene expression data allowed us to predict several genes as candidates for involvement in resistance to IBDV. © 2015, American Society for Microbiology.

Keywords:animal experiment, animal tissue, Article, chicken, controlled study, gene, gene expression, IFITM1 gene, IFITM3 gene, IFITM5 gene, IFNA gene, IFNG gene, infection resistance, infection sensitivity, infectious bursal disease, infectious bursal disease virus, MX1 gene, nonhuman, spleen, upregulation, virus immunity, Aves, Gallus gallus, NotOAChecked
Subjects:D Veterinary Sciences, Agriculture and related subjects > D300 Animal Science
Divisions:College of Science > School of Life Sciences
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ID Code:19848
Deposited On:29 Dec 2015 20:32

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