Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

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Item Type:Article
Item Status:Live Archive

Abstract

Insulin-dependent diabetes mellitus (IDDM) is associated with both antibody and T-cell autoimmunity to pancreatic islet cell components. In recent years, considerable progress has been made in the identification of the molecular components of the pancreatic islets to which these immune responses are directed. These advances have led to the development of a number of immune markers for use in screening for individuals at risk for disease, and there is promise of antigen-specific immune intervention therapies to prevent diabetes in those identified as at risk. In this article, we review our current knowledge of autoantigens associated with IDDM and the implications this has on the prediction and prevention of the disease.

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Keywords:autoantibody, autoantigen, enzyme antibody, glutamate decarboxylase, insulin, insulin antibody, pancreas islet cell antibody, protein tyrosine phosphatase, article, autoimmunity, disease predisposition, human, immune response, insulin dependent diabetes mellitus, nonhuman, pancreas islet cell, prediction, priority journal, t lymphocyte, Autoantibodies, Autoantigens, Biological Markers, Diabetes Mellitus, Type 1, Forecasting, Humans, Islets of Langerhans
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
Divisions:College of Science > School of Life Sciences
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ID Code:18143
Deposited On:08 Aug 2015 15:37

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