IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J. , Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Full content URL: http://care.diabetesjournals.org/content/25/7/1192...

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IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin

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Abstract

OBJECTIVE - The use of cyclosporin in recent-onset type 1 diabetes has demonstrated the potential for immune intervention in the treatment and prevention of the disease. However, a proportion of patients failed to respond to cyclosporin treatment. Indicators of resistance to immune intervention would be valuable for the most effective use of such therapies in disease prevention. The aim of this study was to determine whether presence of IA-2 antibodies is such a marker. RESEARCH DESIGN AND METHODS - IA-2 antibodies were determined by radio-ligand binding assay in sera from patients recruited into the Canadian-European cyclosporin trial. Insulin dose requirements and glucagon-stimulated C-peptide secretion were analyzed in patients grouped according to IA-2 antibody status at entry. RESULTS - Cyclosporin treatment had no significant effect on frequency of IA-2 antibodies during the 1 year of treatment. Cyclosporin caused significant reduction in insulin requirements and significant increases in C-peptide secretion mainly in patients negative for IA-2 antibodies. Analysis of GAD antibodies in combination with antibodies to IA-2 indicated that the group most resistant to cyclosporin were IA-2 antibody positive, GAD antibody negative. CONCLUSIONS - The results demonstrate that IA-2 antibody analysis is valuable in identifying individuals for whom immunosuppressive treatment would be most effective.

Keywords:C peptide, cyclosporin, glucagon, Ia antibody, insulin, antidiabetic agent, autoantibody, glycosylated hemoglobin, ICA512 autoantibody, immunosuppressive agent, placebo, article, human, immunosuppressive treatment, insulin dependent diabetes mellitus, radioassay, remission, adult, blood, clinical trial, comparative study, controlled clinical trial, controlled study, female, follow up, immunology, male, multicenter study, prediction and forecasting, randomized controlled trial, time, Adult, Autoantibodies, C-Peptide, Cyclosporine, Diabetes Mellitus, Type 1, Follow-Up Studies, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Immunosuppressive Agents, Placebos, Predictive Value of Tests, Time Factors
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
Divisions:College of Science > School of Life Sciences
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ID Code:18133
Deposited On:07 Aug 2015 09:41

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