The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

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The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes

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Abstract

The incidence of childhood type 1 diabetes has risen over the past 50 years. We compared the frequency of HLA class II haplotypes in 194 patients diagnosed more than 50 years ago and 582 age-matched and sex-matched individuals diagnosed between 1985 and 2002. The proportion of high-risk susceptibility genotypes was increased in the earlier cohort (p=0·003), especially in those diagnosed at age 5 years or younger, which is consistent with the hypothesis that the rise of type 1 diabetes is due to a major environmental effect.

Keywords:HLA antigen class 2, adolescent, article, childhood disease, cohort analysis, controlled study, female, genetic susceptibility, genotype, haplotype, high risk population, human, incidence, insulin dependent diabetes mellitus, male, priority journal, Adolescent, Age of Onset, Child, Child, Preschool, Diabetes Mellitus, Type 1, Genetic Predisposition to Disease, Haplotypes, Histocompatibility Antigens Class II, HLA-DQ Antigens, HLA-DR Antigens, Humans, Risk
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
Divisions:College of Science > School of Life Sciences
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ID Code:18130
Deposited On:07 Aug 2015 08:22

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