Asymmetric aldol reaction of α,α-disubstituted acetaldehydes catalyzed by Ddphenylprolinol silyl ether for the construction of quaternary stereogenic centers

Hayashi, Yujiro, Shomura, Hiroki, Xu, Qianqian , Lear, Martin and Sato, Itaru (2015) Asymmetric aldol reaction of α,α-disubstituted acetaldehydes catalyzed by Ddphenylprolinol silyl ether for the construction of quaternary stereogenic centers. European Journal of Organic Chemistry, 20 . pp. 4316-4319. ISSN 1434-193X

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Abstract

The asymmetric cross-aldol reaction of α,α-disubstituted acetaldehydes with commercial ethyl glyoxylate polymer was successfully catalyzed by diphenylprolinol silyl ether 3 to generate all-carbon quaternary stereogenic centers with good enantioselectivity.

Keywords:Organocatalysis, Asymmetric synthesis, bmjgoldcheck, NotOAChecked
Subjects:F Physical Sciences > F160 Organic Chemistry
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:17520
Deposited On:07 Jun 2015 17:27

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