Two new paracetamol/dioxane solvates - a system exhibiting a reversible solid-state phase transformation

Vrcelj, Ranko M., Clark, Nathan I.B., Kennedy, Alan R. , Sheen, David B., Shepherd, Evelyn E.A. and Sherwood, John N. (2003) Two new paracetamol/dioxane solvates - a system exhibiting a reversible solid-state phase transformation. Journal of Pharmaceutical Sciences, 92 (10). pp. 2069-2073. ISSN 0022-3549

Full content URL: http://dx.doi.org/10.1002/jps.10477

Documents
Two new paracetamol/dioxane solvates - a system exhibiting a reversible solid-state phase transformation

Request a copy
[img] PDF
10477_ftp[1].pdf - Whole Document
Restricted to Repository staff only

145kB
Item Type:Article
Item Status:Live Archive

Abstract

This work reports on the crystal structures of two dioxane solvates of paracetamol that are true polymorphs. The high temperature phase is an orthorhombic form, space group Pbca, Z = 8, a = 12.6078(3) Å, b = 12.1129(2) Å, c = 13.4138(3) Å, V = 2048.52(7) Å3, (at 295 K) and the low temperature form is monoclinic, space group P21/c, Z = 4, a = 12.325(6) Å, b = 11.965(4) Å, c = 13.384(6) Å, β = 92.01°, V = 1972.6(14)Å3 (at 123 K). The structures of these polymorphs are described as is the interrelationship between the two structures. In addition to the structural interrelationship, it is shown that the two forms undergo a reversible phase transformation. Desolvation of either form generates the stable monoclinic phase of paracetamol

Keywords:Paracetamol, Solvate, Crystallography
Subjects:F Physical Sciences > F131 Crystallography
F Physical Sciences > F130 Structural Chemistry
Divisions:College of Science > School of Pharmacy
ID Code:16738
Deposited On:20 Feb 2015 09:02

Repository Staff Only: item control page