Clinical trials for elderly patients with multiple diseases (CHROMED): a pilot study

Pompilio, Pasquale, Isetta, Valentina, Malinovschi, Andrei, Middlemass, Jo, Munaro, Giulia, Dalmases, Mireia, Janson, Christer, Siriwardena, A. Niroshan, Macis, Roberta, Zanaboni, Paolo, Calverley, Peter, Dellaca, Raffaele and Rosso, Roberto (2014) Clinical trials for elderly patients with multiple diseases (CHROMED): a pilot study. The European Respiratory Journal : official journal of the European Society for Clinical Respiratory Physiology, 44 (Supp58). p. 971. ISSN 0903-1936

Full content URL: http://erj.ersjournals.com/content/44/Suppl_58/P97...

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Clinical trials for elderly patients with multiple diseases (CHROMED): A pilot study
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Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a significant socio-economic burden. It is frequently associated with comorbidities, such as Congestive Heart failure (CHF), that affect patients' health outcomes. Telemedicine-based care models that enable early diagnosis and treatment are advocated to reduce the socioeconomic impact of chronic diseases. CHROMED (www.chromed.eu) is an EU-funded project involving 9 partners from 7 European countries (Italy, Spain, UK, Estonia, Slovenia, Sweden and Norway) aimed at evaluating the impact of a new integrated home care approach to reduce care costs and improve quality of life in COPD.

CHROMED comprises a pilot study, followed by a multi-centric RCT with 300 patients. The CHROMED system includes a forced oscillation technique (FOT) device for self-measurement of lung mechanics (Resmon Pro Diary, Restech srl, Italy), a touch screen for collecting patient's symptoms and, for subjects with CHF comorbidity, a device for measuring heart rate (HR), blood pressure(BP), SpO2 and body temperature (WRIST CLINIC, Medic4all, Israel).

The pilot study included 16 patients (11 COPD, 5 COPD+CHF). The average monitoring period was 48.3±23.4 days resulting in a total of 504 days. The percentage of data correctly received is reported in the table: Lung impedance and breathing pattern (90%); Heart rate (91.7%); Blood pressure (91.7%); SpO2 (74%); Body temperature (71.4%).

During the pilot, one patient was treated pharmacologically for a COPD exacerbation. Offline processing demonstrated that the system identified this event 5 days in advance.

A good acceptability of the system and short-term compliance among patients was found. Lung function, HR and BP provided the most reliable data.

Keywords:multimorbidity, Chronic Obstructive Pulmonary Disease, telemedicine, randomised controlled trial, pilot study, bmjholiday, NotOAChecked
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Social Science > School of Health & Social Care
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ID Code:16406
Deposited On:13 Jan 2015 11:07

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