Clinical trials for elderly patients with multiple diseases (CHROMED): a pilot study

Pompilio, Pasquale, Isetta, Valentina, Malinovschi, Andrei , Middlemass, Jo, Munaro, Giulia, Dalmases, Mireia, Janson, Christer, Siriwardena, A. Niroshan, Macis, Roberta, Zanaboni, Paolo, Calverley, Peter, Dellaca, Raffaele and Rosso, Roberto (2014) Clinical trials for elderly patients with multiple diseases (CHROMED): a pilot study. The European Respiratory Journal : official journal of the European Society for Clinical Respiratory Physiology, 44 (Supp58). p. 971. ISSN 0903-1936

Full content URL: http://erj.ersjournals.com/content/44/Suppl_58/P97...

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Clinical trials for elderly patients with multiple diseases (CHROMED): A pilot study
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Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a significant socio-economic burden. It is frequently associated with comorbidities, such as Congestive Heart failure (CHF), that affect patients' health outcomes. Telemedicine-based care models that enable early diagnosis and treatment are advocated to reduce the socioeconomic impact of chronic diseases. CHROMED (www.chromed.eu) is an EU-funded project involving 9 partners from 7 European countries (Italy, Spain, UK, Estonia, Slovenia, Sweden and Norway) aimed at evaluating the impact of a new integrated home care approach to reduce care costs and improve quality of life in COPD.

CHROMED comprises a pilot study, followed by a multi-centric RCT with 300 patients. The CHROMED system includes a forced oscillation technique (FOT) device for self-measurement of lung mechanics (Resmon Pro Diary, Restech srl, Italy), a touch screen for collecting patient's symptoms and, for subjects with CHF comorbidity, a device for measuring heart rate (HR), blood pressure(BP), SpO2 and body temperature (WRIST CLINIC, Medic4all, Israel).

The pilot study included 16 patients (11 COPD, 5 COPD+CHF). The average monitoring period was 48.3±23.4 days resulting in a total of 504 days. The percentage of data correctly received is reported in the table: Lung impedance and breathing pattern (90%); Heart rate (91.7%); Blood pressure (91.7%); SpO2 (74%); Body temperature (71.4%).

During the pilot, one patient was treated pharmacologically for a COPD exacerbation. Offline processing demonstrated that the system identified this event 5 days in advance.

A good acceptability of the system and short-term compliance among patients was found. Lung function, HR and BP provided the most reliable data.

Keywords:multimorbidity, Chronic Obstructive Pulmonary Disease, telemedicine, randomised controlled trial, pilot study, bmjholiday, NotOAChecked
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Social Science > School of Health & Social Care
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ID Code:16406
Deposited On:13 Jan 2015 11:07

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