Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs

Aloysius, Mark M. and Mc Kechnie, Alastair J. and Robins, Richard A. and Verma, Chandan and Eremin, Jennifer M. and Farzaneh, Farzin and Habib, Nagy A and Bhalla, Joti and Hardwick, Nicola R. and Satthaporn, Sukchai and Sreenivasan, Thiagarajan and El-Sheemy, Mohammed and Eremin, Oleg (2009) Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs. Journal of Translational Medicine, 7 (1). p. 18. ISSN 1479-5876

Full content URL: http://dx.doi.org/10.1186/1479-5876-7-18

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Item Type:Article
Item Status:Live Archive

Abstract

Optimal techniques for DC generation for immunotherapy in cancer are yet to be established. Study aims were to evaluate: (i) DC activation/maturation milieu (TNF-α +/- IFN-α) and its effects on CD8+ hTERT-specific T cell responses to class I epitopes (p540 or p865), (ii) CD8+ hTERT-specific T cell responses elicited by vaccination with class I alone or both class I and II epitope (p766 and p672)-pulsed DCs, prepared without IFN-α, (iii) association between circulating T regulatory cells (Tregs) and clinical responses.

Keywords:Immunotherapy, Cancer immunotherapy
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
Divisions:College of Science > School of Life Sciences
ID Code:9797
Deposited On:10 Jun 2013 09:00

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