Annexins in human breast cancer: possible predictors of pathological response to neoadjuvant chemotherapy

Chuthapisith, Suebwong and Bean, Beverley E. and Cowley, Gerard and Eremin, Jennifer M. and Samphao, Srila and Layfield, Robert and Kerr, Ian D. and Wiseman, Janice and El-Sheemy, Mohamed and Sreenivasan, Thiagarajan and Eremin, Oleg (2009) Annexins in human breast cancer: possible predictors of pathological response to neoadjuvant chemotherapy. European Journal of Cancer, 45 (7). pp. 1274-1281. ISSN 0959-8049

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Neoadjuvant chemotherapy is used in women who have large or locally advanced breast cancers. However, up to 70% of women who receive neoadjuvant chemotherapy fail to achieve a complete pathological response in their primary tumour (a surrogate marker of long-term survival). Five proteins, previously identified to be linked with chemoresistance in our in vitro experiments, were identified histochemically in pre-treatment core needle biopsies from 40 women with large or locally advanced breast cancers. Immunohistochemical staining with the five proteins showed no single protein to be a predictor of response to chemotherapy. However, pre-treatment breast cancer specimens that were annexin-A2 positive but annexin-A1 negative correlated with a poor pathological response (p = 0.04, Fisher’s exact test). The mechanisms by which annexins confer chemoresistance have not been identified, but may be due to inhibition of apoptosis. Annexin-A1 has been shown to enhance apoptosis, whilst annexin-A2, by contrast, inhibits apoptosis

Keywords:Breast cancer, Neoadjuvant chemotherapy, Annexin-A1, Annexin-A2, Pathological response
Subjects:B Subjects allied to Medicine > B130 Pathology
Divisions:College of Science > School of Life Sciences
ID Code:9796
Deposited On:10 Jun 2013 08:48

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