Genetic comparison of large fragment of the 5'untranslated region among foot-and-mouth disease viruses with special reference to serotype Asia1

Biswas, S. and Sanyal, A. and Hemadri, D. and Tosh, C. and Mohapatra, J. K. and Kumar, R. Manoj and Bandyopadhyay, S. K. (2005) Genetic comparison of large fragment of the 5'untranslated region among foot-and-mouth disease viruses with special reference to serotype Asia1. Archives of Virology, 150 (11). pp. 2217-2239. ISSN 0304-8608

Full content URL: http://link.springer.com/article/10.1007%2Fs00705-...

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Item Type:Article
Item Status:Live Archive

Abstract

Foot-and-mouth disease (FMD), the most economically important disease of cloven-hoofed animals, is endemic in India. Sequence analysis revealed that phylogenetic grouping of type Asia1 field isolates on the basis of the large fragment of the 5'untranslated region (5'LF-UTR) was quite similar to that based on the sequences of the capsid-coding (VP1) region of the same viruses. The existence of two distinct lineages of type Asia1 suggested by the study on the VP1 region was further supported by the detection of a difference in length and predicted secondary structure of the 5'LF-UTR between the two lineages. Sequence variability between the isolates of the two lineages was also observed within the different domains of the internal ribosome entry site (IRES) around conserved motifs like the GNRA,- RAAA,- and the polypyrimidine tract. Certain group and lineage-specific signature nucleotides pertaining to FMDV type Asia1 in the 5'LF-UTR have been identified. The present study shows that the 5'LF-UTR of FMDV serotype Asia1 field isolates are variable in relation to the length and probable secondary structure of the IRES.

Keywords:Animal RNA virus, Virology, Veterinary Medicine, RNA structure
Subjects:C Biological Sciences > C540 Virology
C Biological Sciences > C520 Medical and Veterinary Microbiology
C Biological Sciences > C440 Molecular Genetics
Divisions:College of Science > School of Life Sciences
ID Code:9372
Deposited On:10 May 2013 10:22

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