Evidence for reduced neuronal somal size within the insular cortex in schizophrenia, but not in affective disorders

Pennington, Kyla and Dicker, P. and Hudson, L. and Cotter, D. R. (2008) Evidence for reduced neuronal somal size within the insular cortex in schizophrenia, but not in affective disorders. Schizophrenia Research, 106 (2). pp. 164-171. ISSN 0920-9964

Full content URL: http://www.schres-journal.com/article/S0920-9964(0...

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Evidence for reduced neuronal somal size within the insular cortex in schizophrenia, but not in affective disorders

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Abstract

The insular cortex is a paralimbic area of the brain thought to have important roles in sensory integration, auditory hallucinations and language. Both structural and functional MRI studies have revealed that this brain area is abnormal in both size and activity in schizophrenia. Further investigation of this region at the cellular level in schizophrenia has not been carried out. In the current study, we conducted a stereological examination of neuronal and glial size and density
in layers 2 and 3 of the dorso-caudal region of the insular cortex in 15 schizophrenic, 15 bipolar, 15 unipolar and 15 control patients. These cortical layers are candidate layers based on previous cytoarchitectual investigations. Statistical analysis (ANCOVA, correcting for pH, post-mortem interval and age) showed decreased neuronal volume in layer 2 in schizophrenia (p=0.0008, 16.2% mean reduction). No other signi!cant changes were observed. This study thus provides
the !rst evidence of cytoarchitectural abnormality of the insular cortex in the pathophysiology of schizophrenia but not mood disorders. Further work is needed to investigate the molecular basis for this neuronal abnormality in schizophrenia in order to elucidate its role in the pathophysiology of schizophrenia.

Keywords:Schizophrenia, Insular cortex, Layer 2, Neuronal somal size
Subjects:C Biological Sciences > C800 Psychology
C Biological Sciences > C860 Neuropsychology
Divisions:College of Social Science > School of Psychology
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ID Code:9296
Deposited On:02 May 2013 13:20

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