Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: evidence for disease-associated changes

Beasley, Clare L. and Pennington, Kyla and Behan, Aine and Wait, Robin and Dunn, Michael J. and Cotter, David (2006) Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: evidence for disease-associated changes. Proteomics, 6 (11). pp. 3414-3425. ISSN 1615-9853

Full content URL: http://onlinelibrary.wiley.com/doi/10.1002/pmic.20...

Documents
Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: evidence for disease-associated changes

Request a copy
[img] PDF
ACC paper.pdf - Whole Document
Restricted to Repository staff only

751kB
Item Type:Article
Item Status:Live Archive

Abstract

Abnormalities of the anterior cingulate cortex have previously been described in schizophrenia, major depressive disorder and bipolar disorder. In this study 2-DE was performed followed by mass spectrometric sequencing to identify disease-specific protein changes within the anterior cingulate cortex in these psychiatric disorders. The 2-DE system comprised IPGs 4–7 and 6–9 in the first, IEF dimension and SDS-PAGE in the second dimension. Resultant protein spots were
compared between control and disease groups. Statistical analysis indicated that 35 spots were differentially expressed in one or more groups. Proteins comprising 26 of these spots were identified by mass spectroscopy. These represented 19 distinct proteins; aconitate hydratase, malate dehydrogenase, fructose bisphosphate aldolase A, ATP synthase, succinyl CoA ketoacid transferase, carbonic anhydrase, a- and b-tubulin, dihydropyrimidinase-related protein-1 and -2,
neuronal protein 25, trypsin precursor, glutamate dehydrogenase, glutamine synthetase, sorcin, vacuolar ATPase, creatine kinase, albumin and guanine nucleotide binding protein b subunit. All but three of these proteins have previously been associated with the major psychiatric disorders. These findings provide support for the view that cytoskeletal and mitochondrial dysfunction are important components of the neuropathology of the major psychiatric disorders.

Additional Information:Article first published online: 24 APR 2006
Keywords:Bipolar disorder, 2-D gel electrophoresis, Metabolic, Postmortem, Schizophrenia
Subjects:C Biological Sciences > C800 Psychology
C Biological Sciences > C860 Neuropsychology
Divisions:College of Social Science > School of Psychology
ID Code:9289
Deposited On:02 May 2013 08:11

Repository Staff Only: item control page