Accumulation and intracellular fate of tellurite in tellurite-resistant Escherichia coli: a model for the mechanism of resistance

Lloyd-Jones, Gareth and Osborn, A. Mark and Ritchie, Donald A. and Strike, Peter and Hobman, Jon L. and Brown, Nigel L. and Rouch, Duncan A. (1994) Accumulation and intracellular fate of tellurite in tellurite-resistant Escherichia coli: a model for the mechanism of resistance. FEMS Microbiology Letters, 118 (1-2). pp. 113-119. ISSN 0378-1097

Full content URL: http://dx.doi.org/10.1111/j.1574-6968.1994.tb06812...

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Item Type:Article
Item Status:Live Archive

Abstract

The tellurite accumulation properties of three Escherichia coli strains containing different tellurium-resistance determinants of Gram-negative origin, from plasmids pMER610, pHH1508a and RK2, were compared. In all three cases membrane-associated tellurium crystallization was observed, and neither reduced uptake nor increased export contributed to the resistance. Specific membrane-proximal reduction is proposed as the mechanism of resistance to tellurite coded by all three determinants, despite their lack of sequence homology.

Keywords:tellurite, unclassified drug, article, drug resistance, escherichia coli, nonhuman, priority journal, toxicity, Crystallization, Drug Resistance, Microbial, Models, Biological, Oxidation-Reduction, Plasmids, Support, Non-U.S. Gov't, Tellurium
Subjects:C Biological Sciences > C180 Ecology
C Biological Sciences > C500 Microbiology
Divisions:College of Science > School of Life Sciences
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ID Code:8978
Deposited On:06 May 2013 19:16

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