When phage, plasmids, and transposons collide: genomic islands, and conjugative- and mobilizable-transposons as a mosaic continuum

Osborn, A. Mark and Boltner, Dietmar (2002) When phage, plasmids, and transposons collide: genomic islands, and conjugative- and mobilizable-transposons as a mosaic continuum. Plasmid, 48 (3). pp. 202-212. ISSN 0147-619X

Full content URL: http://dx.doi.org/10.1016/S0147-619X(02)00117-8

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Item Type:Article
Item Status:Live Archive

Abstract

Plasmids and bacteriophage represent the classical vectors for gene transfer within the horizontal gene pool. However, the more recent discovery of an increasing array of other mobile genetic elements (MGE) including genomic islands (GIs), conjugative transposons (CTns), and mobilizable transposons (MTns) which each integrate within the chromosome, offer an increasingly diverse assemblage contributing to bacterial adaptation and evolution. Molecular characterisation of these elements has revealed that they are comprised of functional modules derived from phage, plasmids, and transposons, and further that these modules are combined to generate a continuum of mosaic MGE. In particular, they are comprised of any one of three distinct types of recombinase, together with plasmid-derived transfer and mobilisation gene functions. This review highlights both the similarities and distinctions between these integrating transferable elements resulting from combination of the MGE toolbox. © 2002 Elsevier Science (USA). All rights reserved.

Keywords:gene product, recombinase, resolvase, adaptation, article, bacteriophage, bacterium, chromosome, conjugation, evolution, expression vector, gene function, gene pool, gene transfer, genome, horizontal gene transfer, molecular biology, nonhuman, plasmid, transposon, Bacteriophages, Chromosomes, Bacterial, Conjugation, Genetic, DNA Nucleotidyltransferases, DNA Transposable Elements, Models, Genetic, Mosaicism, Plasmids, Recombinases, Transposases, Transposon Resolvases, Tyrosine, Bacteria (microorganisms), transposons
Subjects:C Biological Sciences > C500 Microbiology
Divisions:College of Science > School of Life Sciences
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ID Code:8962
Deposited On:29 May 2013 07:48

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