Effect of a medication management training package for nurses on clinical outcomes for patients with schizophrenia: cluster randomised controlled trial

Gray, Richard and Wykes, Til and Edmonds, Melisa and Leese, Morven and Gournay, Kevin (2004) Effect of a medication management training package for nurses on clinical outcomes for patients with schizophrenia: cluster randomised controlled trial. The British Journal of Psychiatry (185). pp. 157-162. ISSN 1472-1465

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Official URL: http://dx.doi.org/10.1192/bjp.185.2.157

Abstract

Background Non-compliance attenuates the efficacy of treatments for physical and mental disorders.

Aims To assess the effectiveness of a medication management training package for community mental health nurses (CMHNs) in improving compliance and clinical outcomes in patients with schizophrenia.

Method Pragmatic randomised controlled trial. Sixty CMHNs in geographical clusters were assigned randomly to medication management training or treatment as usual. Each CMHN identified two patients on their case-load who were assessed at baseline and again after 6 months by a research worker. The primary efficacy outcome of interest was psychopathology, measured using the Positive and Negative Syndrome Scale (PANSS).

Results Nurses who had received medication management training produced a significantly greater reduction in patients'overall psychopathology compared with treatment as usual at the end of the 6-month study period (change in PANSS total scores: medication management -16.62, treatment as usual 1.17; difference -17.79; 95% CI -24.12 to -11.45; P<0.001).

Conclusions Medication management training for CMHNs is effective in improving clinical outcomes in patients with schizophrenia.

Item Type:Article
Additional Information:Background Non-compliance attenuates the efficacy of treatments for physical and mental disorders. Aims To assess the effectiveness of a medication management training package for community mental health nurses (CMHNs) in improving compliance and clinical outcomes in patients with schizophrenia. Method Pragmatic randomised controlled trial. Sixty CMHNs in geographical clusters were assigned randomly to medication management training or treatment as usual. Each CMHN identified two patients on their case-load who were assessed at baseline and again after 6 months by a research worker. The primary efficacy outcome of interest was psychopathology, measured using the Positive and Negative Syndrome Scale (PANSS). Results Nurses who had received medication management training produced a significantly greater reduction in patients'overall psychopathology compared with treatment as usual at the end of the 6-month study period (change in PANSS total scores: medication management -16.62, treatment as usual 1.17; difference -17.79; 95% CI -24.12 to -11.45; P<0.001). Conclusions Medication management training for CMHNs is effective in improving clinical outcomes in patients with schizophrenia.
Keywords:Schizophrenia, Randomised control trial, Medication management training
Subjects:B Subjects allied to Medicine > B700 Nursing
Divisions:College of Social Science > School of Health & Social Care
ID Code:889
Deposited By: Jill Partridge
Deposited On:27 Sep 2007
Last Modified:13 Mar 2013 08:24

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