Using a virtual cortical module implementing a neural field model to modulate brain rhythms in Parkinson’s disease

Modolo, Julien and Bhattacharya, Basabdatta and Edwards, Roderick and Campagnaud, julien and Legros, Alexandre and Beuter, Anne (2010) Using a virtual cortical module implementing a neural field model to modulate brain rhythms in Parkinson’s disease. Frontiers in Neuroscience, 4 (45). pp. 1-11. ISSN 1662-4548

Full content URL: http://dx.doi.org/10.3389/fnins.2010.00045

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Abstract

We propose a new method for selective modulation of cortical rhythms based on neural field theory, in which the activity of a cortical area is extensively monitored using a two-dimensional microelectrode array. The example of Parkinson’s disease illustrates the proposed method, in which a neural field model is assumed to accurately describe experimentally recorded activity. In addition, we propose a new closed-loop stimulation signal that is both space- and time- dependent. This method is especially designed to specifically modulate a targeted brain rhythm, without interfering with other rhythms. A new class of neuroprosthetic devices is also proposed, in which the multielectrode array is seen as an artificial neural network interacting with biological tissue. Such a bio-inspired approach may provide a solution to optimize interactions between the stimulation device and the cortex aiming to attenuate or augment specific cortical rhythms. The next step will be to validate this new approach experimentally in patients with Parkinson’s disease.

Keywords:brain stimulation, dysrhythmia, neural field model, Parkinson’s disease, neuroprosthetic devices
Subjects:B Subjects allied to Medicine > B140 Neuroscience
Divisions:College of Science > School of Engineering
ID Code:8871
Deposited On:11 Apr 2013 16:36

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