Polymorphism in molecular crystals: stabilization of a metastable form by conformational mimicry

Davey, R. J. and Blagden, N. and Potts, G. D. and Docherty, R. (1997) Polymorphism in molecular crystals: stabilization of a metastable form by conformational mimicry. Journal of the American Chemical Society, 119 (7). pp. 1767-1772. ISSN 0002-7863

Full content URL: http://dx.doi.org/10.1021/ja9626345

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Polymorphism in molecular crystals: stabilization of a metastable form by conformational mimicry

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Abstract

A combined modeling and experimental strategy has been applied to the problem of stabilisation of a metastable conformational polymorph. For the first time additives have been successfully selected which by virtue of their conformation are able to selectively inhibit the appearance of the stable β polymorph of L-glutamic acid and hence stabilize the metastable α structure.

Additional Information:Publication Date (Web): February 19, 1997
Keywords:glutamic acid, article, crystallography, drug stability, drug structure, protein polymorphism
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Pharmacy
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ID Code:8783
Deposited On:03 Apr 2013 13:56

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