Crystal chemistry and solvent effects in polymorphic systems: Sulfathiazole

Blagden, Nicholas and Davey, R. J. and Lieberman, H. F. and Williams, L. and Payne, R. and Roberts, R. and Rowe, R. and Docherty, R. (1998) Crystal chemistry and solvent effects in polymorphic systems: Sulfathiazole. Journal of the Chemical Society - Faraday Transactions, 94 (8). pp. 1035-1044. ISSN 0956-5000

Full content URL: http://pubs.rsc.org/en/Content/ArticleLanding/1998...

Full text not available from this repository.

Item Type:Article
Item Status:Live Archive

Abstract

Sulfathiazole, a compound that forms four known crystal structures, has been examined with a view to understanding its polymorphism. A graph set approach was used to classify the structural differences and similarities of the polymorphs, the results of which indicated packing motifs common to three of the four structures. By combining this analysis with experimental morphological data, it has been possible to examine the origins of the observed solvent dependence of polymorph appearance in this system. In particular, the possible link between the observed hydrogen-bond motifs of each form and the associated processes of nucleation and crystal growth from n-propanol, nitromethane, ethanol, water and ammonia solution, have been considered.

Additional Information:cited By (since 1996) 84
Keywords:crystal chemistry, solvent effects, polymorphs, Sulfathiazole
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Pharmacy
Related URLs:
ID Code:8782
Deposited On:03 Apr 2013 15:51

Repository Staff Only: item control page