Crystal polymorphism as a probe for molecular self-assembly during nucleation from solutions: the case of 2,6-dihydroxybenzoic acid

Davey, R. J. and Blagden, Nicholas and Righini, S. and Alison, H. and Quayle, M. J. and Fuller, S. (2001) Crystal polymorphism as a probe for molecular self-assembly during nucleation from solutions: the case of 2,6-dihydroxybenzoic acid. Crystal Growth and Design, 1 (1). pp. 59-65. ISSN 1528-7483

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Item Type:Article
Item Status:Live Archive

Abstract

The relationship between molecular self-assembly processes and nucleation during crystallization from solution is an important issue, both in terms of fundamental physical chemistry and for the control and application of crystallization processes in crystal engineering and materials chemistry. This contribution examines the extent to which the occurrence of crystal polymorphism can be used as an indicator of the nature of molecular aggregation processes in supersaturated solutions. For the specific case of 2,6-dihydroxybenzoic acid a combination of solubility, spectroscopic, crystallization, and molecular modeling techniques are used to demonstrate that there is a direct link between the solvent-induced self-assembly of this molecule and the relative occurrence of its two polymorphic forms from toluene and chloroform solutions. © 2001 American Chemical Society.

Keywords:Crystals
Subjects:B Subjects allied to Medicine > B230 Pharmacy
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Pharmacy
ID Code:8775
Deposited On:04 Apr 2013 11:27

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