Nucleation control in solution mediated polymorphic phase transformations: the case of 2,6-dihydroxybenzoic acid

Davey, R. J. and Blagden, N. and Righini, S. and Alison, H. and Ferrari, E. S. (2002) Nucleation control in solution mediated polymorphic phase transformations: the case of 2,6-dihydroxybenzoic acid. Journal of Physical Chemistry B, 106 (8). pp. 1954-1959. ISSN 1520-6106

Full content URL: http://dx.doi.org/10.1021/jp013044i

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Item Type:Article
Item Status:Live Archive

Abstract

This contribution describes the kinetics of the solution mediated phase transformation between forms 1 and 2 of dihydroxybenzoic acid. It is shown how a combination of kinetic, morphological, and modeling data can be used to give a full description of the rate-determining process in such a transformation. Surprisingly, secondary nucleation is found to dominate the kinetic processes. Such a phenomenon is well-known in continuous crystallization but is reported here for the first time in a polymorphic phase transformation. This observation has significant consequences for process and product control in the pharmaceutical and specialty chemicals industries.

Keywords:Polymorphic modifications, Carboxylic acids, Computer simulation, Crystallization, Drug products plants, Nucleation, Phase transitions, Reaction kinetics
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Pharmacy
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ID Code:8774
Deposited On:26 Jul 2013 14:21

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