Current directions in co-crystal growth

Blagden, Nicholas and Berry, David J. and Parkin, Aandrew and Javed, Hafsa and Ibrahim, Asim and Gavan, Pauline T. and De Matos, Luciana L. and Seaton, Colin C. (2008) Current directions in co-crystal growth. New Journal of Chemistry, 32 (10). pp. 1659-1672. ISSN 1144-0546

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In this feature article we will focus on the issues relating to the crystal growth of co-crystals, with a particular emphasis on drug development. The initial focus of this perspective is on the relevant literature examples that may be able to inform our understanding with regards co-crystal crystallisation and the allied supramolecular concepts. The second part of this perspective contains selected examples from our own work, which add to the literature perspective. Topics include; nucleation templates, in situ synchrotron XRD studies, solid-state synthesis through mixing and screening strategies. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

Keywords:benzamide, benzoic acid, fumaric acid, ibuprofen, isonicotinamide, nicotinamide, crystal structure, crystallization, hydrogen bond, microscopy, particle size, physical chemistry, priority journal, review, solid state, supramolecular chemistry, synchrotron, synthesis, X ray diffraction
Subjects:B Subjects allied to Medicine > B230 Pharmacy
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Pharmacy
ID Code:8760
Deposited On:22 Apr 2013 09:38

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