Interactions of cells with elastic cholesteryl liquid crystals

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

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Item Type:Conference or Workshop contribution (Paper)
Item Status:Live Archive

Abstract

Exploitation of elastic property of the liquid crystal to sense cells mechanics is a novel application. Both quantitative and qualitative analysis of cholesteryl liquid crystal has shown flexibility and elasticity of the material to sense cell contraction and relaxation over a period of time. Importantly, cells adhesion was precluded with the use of extracellular matrix proteins in this technique. The optimum operating range with linear elasticity of the cholesteryl liquid crystal is � 0.1s -1 which has a good correlation with the shear rate of the cells originated from the focal adhesions. Localized contraction was observed with a good resolution. In addition, clear definition of deformation lines between two cells has shown their interacting path through active mechano-sensing. © 2009 Springer-Verlag.

Additional Information:Conference of World Congress on Medical Physics and Biomedical Engineering: Biomaterials, Cellular and Tissue Engineering, Artificial Organs; Conference Date: 7 September 2009 through 12 September 2009; Conference Code: 81639
Keywords:Cell contraction, Cell mechanic, Cells adhesion, Elastic properties, Extracellular matrix protein, Focal adhesions, Good correlations, Human keratinocytes, Linear elasticity, Novel applications, Operating ranges, Qualitative analysis, Shear rates, Adhesion, Artificial organs, Cell adhesion, Crystals, Elasticity, Liquid crystals, Mechanics, Proteins, Shear deformation, Tissue engineering, Cells
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Pharmacy
ID Code:8755
Deposited On:29 Jul 2013 09:12

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