Solubility of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2 K

Ali, Hany S. M. and York, Peter and Blagden, Nicholas and Soltanpour, Shahla and Acree Jr., William E. and Jouyban, Abolghasem (2010) Solubility of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2 K. Journal of Chemical and Engineering Data, 55 (1). pp. 578-582. ISSN 0021-9568

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Abstract

Experimental solubilities of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2 K are reported. The solubility of drugs was increased with the addition of ethanol and reached the maximum values of the volume fractions of 90, 80, and 80 of ethanol. The Jouyban-Acree model was used to fit the experimental data, and the solubilities were reproduced using previously trained versions of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 5.1, 6.4, 37.7, and 35.9, respectively, for the fitted model, the trained version for ethanol + water mixtures, and generally trained versions for various organic solvents + water mixtures. Solubilities were also predicted by a previously established log-linear model of Yalkowsky with the OMRD of 53.8. © 2010 American Chemical Society.

Additional Information:Publication Date (Web): September 14, 2009
Keywords:Experimental data, Jouyban-Acree model, Loglinear model, Maximum values, Prednisolone, Relative deviations, Solubility data, Water mixture, Capillary flow, Ethanol, Mixtures, Organic solvents, Regression analysis, Ternary systems, Solubility
Subjects:F Physical Sciences > F170 Physical Chemistry
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Pharmacy
ID Code:8754
Deposited On:22 Apr 2013 08:50

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