Influence of solvent on the morphology and subsequent comminution of ibuprofen crystals by air jet milling

Shariare, Mohammad H. and Blagden, Nicholas and de Matas, Marcel and Leusen, Frank J. J. and York, Peter (2012) Influence of solvent on the morphology and subsequent comminution of ibuprofen crystals by air jet milling. Journal of Pharmaceutical Sciences, 101 (3). pp. 1108-1119. ISSN 0022-3549

Full content URL: http://dx.doi.org/10.1002/jps.23003

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Item Type:Article
Item Status:Live Archive

Abstract

Crystal morphology plays an important role in drug processing and delivery, which may be controlled during crystallisation. In this study, ibuprofen particles with different size and morphology were produced by controlled crystallisation in order to evaluate their impact on particle size reduction. Results suggest that the micronisation behaviour of ibuprofen was markedly influenced by the morphology and size of starting materials. It was possible to reduce the size of ibuprofen particles to sizes less than 5 μm during dry milling, which is markedly below the reported brittle-ductile transition size. Results also indicate that the particle size reduction mechanism is influenced by the size and morphology of the starting ibuprofen crystals. Dissolution behaviour of ibuprofen was shown to be influenced by the solid surface chemistry of micronised drug particles. The molecular modelling study provided deeper understanding of the experimental findings observed in this study. © 2011 Wiley Periodicals, Inc.

Keywords:ibuprofen, solvent, air jet milling, article, crystal structure, crystallization, drug solubility, high performance liquid chromatography, inverse gas chromatography, molecular model, morphology, particle size, pharmacological procedures, phase transition, scanning electron microscopy, surface property, Analgesics, Non-Narcotic, Drug Compounding, Models, Molecular, Solubility, Solvents
Subjects:B Subjects allied to Medicine > B230 Pharmacy
Divisions:College of Science > School of Pharmacy
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ID Code:8746
Deposited On:04 Apr 2013 09:19

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