Prediction of protein tertiary structure class from synchrotron radiation circular dichroism spectra

Procopiou, A. and Allinson, Nigel and Jones, G. R. and Clarke, D. T. (2006) Prediction of protein tertiary structure class from synchrotron radiation circular dichroism spectra. In: 6th International Workshop on Pattern Recognition in Information Systems, PRIS 2006, in Conjunction with ICEIS 2006, 23-17 May 2006, Paphos, Greece.

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Item Type:Conference or Workshop contribution (Paper)
Item Status:Live Archive

Abstract

A new approach to predict the tertiary structure class of proteins from synchrotron radiation circular dichroism (SRCD) spectra is presented. A protein's SRCD spectrum is first approximated using a Radial Basis Function Network (RBFN) and the resulting set is used to train different varieties of Support Vector Machine (SVM). The performance of three well known multi-class SVM schemes are evaluated and a method presented that takes into account the properties of spectra for each of the structure classes.

Keywords:Multiclass SVM, New approaches, Protein tertiary structures, Synchrotron radiation circular dichroisms, Tertiary structures, Dichroism, Information systems, Proteins, Radial basis function networks, Synchrotron radiation, Synchrotrons, Pattern recognition systems
Subjects:G Mathematical and Computer Sciences > G400 Computer Science
G Mathematical and Computer Sciences > G740 Computer Vision
Divisions:College of Science > School of Computer Science
ID Code:8557
Deposited On:10 Apr 2013 15:54

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