The effect of endotoxin and anti-endotoxin serum on synovial fluid parameters in the horse

Gottschalk, R. D. and Reyers, Fred and van den Berg, S. S. (1998) The effect of endotoxin and anti-endotoxin serum on synovial fluid parameters in the horse. Journal of the South African Veterinary Association, 69 (1). pp. 7-11. ISSN 1019-9128

Full content URL: http://www.jsava.co.za/index.php/jsava/article/vie...

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Item Type:Article
Item Status:Live Archive

Abstract

The effects of a commercially available equine hyperimmune anti-endotoxin serum on synovial fluid parameters were evaluated in an induced synovitis model in normal horses. Four groups of 3 horses each received lipopolysaccharide (LPS) plus hyperimmune antiendotoxin (anti-LPS), LPS, anti-LPS, and Ringers lactate (control) respectively injected into the left intercarpal joint. Synovial fluid parameters were measured at 4, 8, 24 and 72 h. It was found that anti-LPS had no attenuating effect on the LPS and that it induced a synovitis almost equivalent to that induced by LPS alone. The introduction of sterile Ringers lactate solution into the carpal joint together with repeated aseptic arthrocentesis induces a mild inflammatory response.

Keywords:Horse
Divisions:College of Science > School of Life Sciences
ID Code:8476
Deposited On:31 Mar 2013 18:16

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