Regulation of neural process growth, elaboration and structural plasticity by NF-κB

Gutierrez, Humberto and Davies, Alun M. (2011) Regulation of neural process growth, elaboration and structural plasticity by NF-κB. Trends in Neurosciences, 34 (6). pp. 316-25. ISSN 0166-2236

Full content URL: htto://dx.doi.oeg/10.1016/j.tins.2011.03.001

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Item Type:Article
Item Status:Live Archive

Abstract

The nuclear factor-kappa B (NF-κB) family of transcription factors has recently emerged as a major regulator of the growth and elaboration of neural processes. NF-κB signaling has been implicated in controlling axon initiation, elongation, guidance and branching and in regulating dendrite arbor size and complexity during development and dendritic spine density in the adult. NF-κB is activated by a variety of extracellular signals, and either promotes or inhibits growth depending on the phosphorylation status of the p65 NF-κB subunit. These novel roles for NF-κB, together with recent evidence implicating NF-κB in the regulation of neurogenesis in the embryo and adult, have important implications for neural development and for learning and memory in the mature nervous system.

Keywords:Neuronal Development
Subjects:C Biological Sciences > C141 Developmental Biology
Divisions:College of Science > School of Life Sciences
ID Code:7852
Deposited On:23 Mar 2013 17:58

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