Hydrocortisone nanosuspensions for ophthalmic delivery: a comparative study between microfluidic nanoprecipitation and wet milling

Ali, Hany S. M. and York, Peter and Ali, Ahmed M. A. and Blagden, Nicholas (2011) Hydrocortisone nanosuspensions for ophthalmic delivery: a comparative study between microfluidic nanoprecipitation and wet milling. Journal of Controlled Release, 149 (2). pp. 175-181. ISSN 0168-3659

Full content URL: http://dx.doi.org/10.1016/j.jconrel.2010.10.007

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Abstract

Recently, drug nanosuspensions have shown a potential for ophthalmic delivery. In this study, a hydrocortisone (HC) nanosuspension (NS) was developed using microfluidic nanoprecipitation as a recent, simple and cost-effective bottom-up technique of drug nanonization. For comparison, a second HC NS was prepared by top-down wet milling procedures. The produced nanosuspensions were characterized for particle size, shape and zeta potential. HC nanosuspensions of approximately 300 nm particle size were produced by adjusting experimental conditions of the two processing techniques. Results of X-ray diffraction and differential scanning calorimetry revealed that HC maintained the crystalline structure upon milling, while predominant amorphous particles were generated after precipitation. Ocular bioavailability of HC nanosuspensions was assessed in albino rabbits using HC solution as a control. A sustained drug action was maintained up to 9 h for the nanosuspensions compared to 5 h for the drug solution. The precipitated and milled NS achieved comparable AUC(0-9h) values of 28.06 +/- 4.08 and 30.95 +/- 2.2, respectively, that were significantly (P<0.05) higher than that of HC solution (15.86 +/- 2.7). After 2 months storage at room temperature, the milled HC NS showed good stability with no discernable changes in particle size, whereas the particle size of the precipitated HC NS increased to 440 nm

Keywords:Hydrocortisone, Controlled release, Nanosuspension, Milling, Microfluidics, Ophthalmic delivery
Subjects:F Physical Sciences > F131 Crystallography
B Subjects allied to Medicine > B230 Pharmacy
F Physical Sciences > F170 Physical Chemistry
F Physical Sciences > F290 Materials Science not elsewhere classified
Divisions:College of Science > School of Pharmacy
ID Code:7701
Deposited On:28 Feb 2013 07:51

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