Elucidation of trends within venom components from the snake families Elapidae and Viperidae using gel filtration chromatography

Graham, Robert Leslie James and Graham, Ciaren and Theakson, David and McMullan, Geoff and Shaw, Chris (2008) Elucidation of trends within venom components from the snake families Elapidae and Viperidae using gel filtration chromatography. Toxicon, 51 (1). pp. 121-129. ISSN 0041-0101

Full content URL: http://dx.doi.org/10.1016/j.toxicon.2007.08.010

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Item Type:Article
Item Status:Live Archive

Abstract

Research into snake venom components has intensified over the last number of decades, particularly that work directed towards the discovery of novel agents with potential applications in clinical therapy. In the present study we report, for the first time, defined patterns observed in the G-50 chromatographic elution profiles from 30 snake venoms taken from Elapidae and Viperidae families, as well as previously unreported patterns within subfamilies of these snake species. Development of this chromatographic technique thus offers a rapid method for the general classification of snakes within these families as well as providing insights into hitherto uncharacterised trends within the venoms of snake subfamilies that have opened new avenues for further investigation.

Keywords:Snake Venom, Novel drug therapies, Elapidae, Viperidae, Chromatography
Subjects:C Biological Sciences > C720 Biological Chemistry
B Subjects allied to Medicine > B290 Pharmacology, Toxicology and Pharmacy not elsewhere classified
Divisions:College of Science > School of Life Sciences
ID Code:7330
Deposited On:23 Jan 2013 17:06

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