An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne

Spiteri, Christian and Mason, Christopher and Zhang, Fengzhi and Ritson, Dougal J. and Sharma, Pallavi and Keeling, Steve and Moses, John E. (2010) An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. Organic and Biomolecular Chemistry Articles, 8 (11). pp. 2537-2542. ISSN 1477-0520

Full content URL: http://pubs.rsc.org/en/content/articlelanding/2010...

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Item Type:Article
Item Status:Live Archive

Abstract

An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reactants simultaneously.

Additional Information:An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reactants simultaneously.
Keywords:Benzisoxazole, benzyne, 1, 3-dipolar cycloaddition
Subjects:F Physical Sciences > F160 Organic Chemistry
Divisions:College of Science > School of Life Sciences
ID Code:7108
Deposited On:21 Dec 2012 14:49

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