Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5

Moorhouse, Adam D. and Spiteri, Christian and Sharma, Pallavi and Zloh, Mire and Moses, John E. (2011) Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5. Chemical Communications, 47 (1). pp. 230-232. ISSN 1359-7345

Full content URL: http://pubs.rsc.org/en/content/articlelanding/2011...

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Item Type:Article
Item Status:Live Archive

Abstract

hLDH-5 has emerged as a promising target for anti-glycolytic cancer chemotherapy. Here we report a first generation of bifunctional inhibitors, which show promising activity against hLDH-5.

Keywords:Lactate dehydrogenase, glycolysis, Click-chemistry
Subjects:F Physical Sciences > F160 Organic Chemistry
Divisions:College of Science > School of Life Sciences
ID Code:7106
Deposited On:21 Dec 2012 12:20

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