Microwave enhanced tandem azidation-amidation of anilines

Sharma, Pallavi and Moorhouse, Adam D. and Moses, John E. (2011) Microwave enhanced tandem azidation-amidation of anilines. Synlett, 2011 (16). pp. 2384-2386. ISSN 0936-5214

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Item Type:Article
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Abstract

An efficient entry to aromatic amides using microwave irradiation in aqueous medium is described. Starting from substituted anilines, in situ formation of the corresponding aromatic azide is followed by their immediate reaction with a thioacid to yield amides in excellent yield. This improved protocol significantly reduces the reaction time thus increasing the overall efficiency of this useful transformation.

Additional Information:An efficient entry to aromatic amides using microwave irradiation in aqueous medium is described. Starting from substituted anilines, in situ formation of the corresponding aromatic azide is followed by their immediate reaction with a thioacid to yield amides in excellent yield. This improved protocol significantly reduces the reaction time thus increasing the overall efficiency of this useful transformation.
Keywords:amide, azide, thio-acid
Subjects:F Physical Sciences > F160 Organic Chemistry
Divisions:College of Science > School of Life Sciences
ID Code:7103
Deposited On:14 Dec 2012 13:51

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