Helicase–primase inhibitors: a new approach to combat herpes simplex virus and varicella zoster virus

Biswas, Subhajit and Field, Hugh J. (2011) Helicase–primase inhibitors: a new approach to combat herpes simplex virus and varicella zoster virus. In: Antiviral Drug Strategies. Methods and Principles in Medicinal Chemistry . Wiley-VCH Verlag GmbH & Co. KGaA, pp. 129-146. ISBN 9783527635955, 9783527326969

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/9783527...

Abstract

This chapter (no. 6) contains sections titled:

1. Introduction

2. The Role of Helicase Primase in the Replication of HSV

3. Selective Inhibitors of Helicase Primase as Antiherpesvirus Antivirals

4. HPIs are Effective in Cell Culture and In Vivo

5. Effects of HPIs on the Establishment and Reactivation from Latency

6. HPIs: The Biochemical Basis for the Proposed Mechanism of Action

7. HSV Acquired Resistance to HPIs

8. Patterns of Cross-Resistance

9. Further Insight into Mode of HPI Interaction with the HSV HP Complex from the Study of Resistance Mutations

10. The Frequency and Origin of HPI-Resistance Mutations

11. UL5 Lys356Asn: a Mutation Conferring High Resistance to HPI

12. The Origin of Resistance Mutations at High Frequency

13. Conclusions

14. References

Item Type:Book Section
Additional Information:This chapter (no. 6) contains sections titled: 1. Introduction 2. The Role of Helicase Primase in the Replication of HSV 3. Selective Inhibitors of Helicase Primase as Antiherpesvirus Antivirals 4. HPIs are Effective in Cell Culture and In Vivo 5. Effects of HPIs on the Establishment and Reactivation from Latency 6. HPIs: The Biochemical Basis for the Proposed Mechanism of Action 7. HSV Acquired Resistance to HPIs 8. Patterns of Cross-Resistance 9. Further Insight into Mode of HPI Interaction with the HSV HP Complex from the Study of Resistance Mutations 10. The Frequency and Origin of HPI-Resistance Mutations 11. UL5 Lys356Asn: a Mutation Conferring High Resistance to HPI 12. The Origin of Resistance Mutations at High Frequency 13. Conclusions 14. References
Keywords:cross-resistance, helicase–primase complex, HPI-resistant mutants, latent infection, nucleoside analogues, plaque reduction assay
Subjects:C Biological Sciences > C540 Virology
C Biological Sciences > C520 Medical and Veterinary Microbiology
A Medicine and Dentistry > A300 Clinical Medicine
F Physical Sciences > F151 Pharmaceutical Chemistry
Divisions:College of Science > School of Life Sciences
ID Code:6963
Deposited By: Subhajit Biswas
Deposited On:26 Nov 2012 17:53
Last Modified:26 Nov 2012 17:53

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