Mohapatra, Jajati K. and Sanyal, Aniket and Hemadri, Divakar and Tosh, Chakradhar and Biswas, Subhajit and Knowles, Nick J. and Rasool, Thaha J. and Bandyopadhyay, Santanu K. and Pattnaik, Bramhadev (2008) Comparative genomics of serotype Asia 1 foot-and-mouth disease virus isolates from India sampled over the last two decades. Virus Research, 136 (1-2). pp. 16-29. ISSN 0168-1702
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This study deals with a comparative analysis of complete genome sequences of twenty-one serotype Asia 1 foot-and-mouth disease (FMD) field viruses isolated over a period of two decades from India, two vaccine strains and seven exotic sequences. The Indian viruses could be grouped in to three distinct lineages at the entire coding region, evolving independently probably under differential selection pressure as evident from the lineage-specific signatures identified. This comparison revealed 80% of amino acids at the polyprotein region to be invariant. Twenty-one residues in L, 3A and P1 region were identified to be under positive selection of which some are antigenically critical. Analysis at functionally crucial motifs, receptor contact residues, polyprotein cleavage sites and at putative T-cell epitopes expands the knowledge beyond other serotypes. Antigenic site II in betaB-betaC loop of VP2 was highly unstable suggesting its exposure to extreme immune pressure. A single cross-over at the L proteinase region in an isolate from buffalo, also featuring an extensive deletion at the 5' untranslated region (UTR), reflects the role of intraserotypic genetic recombination in natural evolution. The likely biological relevance of deletions/insertions observed at UTRs, VP1 and 3A could not be deduced. Altogether, a substantial amount of data raised on full length genomes of type Asia 1 virus adds value to the FMD virus genomics.
|Keywords:||virus, foot-and-mouth disease, India, Asia 1 serotype, epidemiology|
|Subjects:||C Biological Sciences > C522 Veterinary Microbiology|
C Biological Sciences > C540 Virology
D Veterinary Sciences, Agriculture and related subjects > D320 Animal Health
|Divisions:||College of Science > School of Life Sciences|
|Deposited On:||26 Nov 2012 14:22|
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