Regulation of G protein-coupled receptors by palmitoylation and cholesterol

Goddard, Alan and Watts, Anthony (2012) Regulation of G protein-coupled receptors by palmitoylation and cholesterol. BMC Biology, 10 (27). ISSN 1741-7007

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Official URL: http://dx.doi.org/10.1186/1741-7007-10-27

Abstract

Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.

Item Type:Article
Additional Information:Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.
Keywords:GPCR, Palmitoylation, Cholesterol
Subjects:C Biological Sciences > C700 Molecular Biology, Biophysics and Biochemistry
Divisions:College of Science > School of Life Sciences
ID Code:6846
Deposited By: Alan Goddard
Deposited On:16 Nov 2012 12:07
Last Modified:16 Nov 2012 12:07

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