Goddard, Alan and Watts, Anthony (2012) Regulation of G protein-coupled receptors by palmitoylation and cholesterol. BMC Biology, 10 (27). ISSN 1741-7007

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Abstract

Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.

Item Type:	Article
Additional Information:	Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.
Keywords:	GPCR, Palmitoylation, Cholesterol
Subjects:	C Biological Sciences > C700 Molecular Biology, Biophysics and Biochemistry
Divisions:	College of Sciences > Faculty of Science > School of Life Sciences
Depositing User:	Alan Goddard
Date Deposited:	16 Nov 2012 12:07
Last Modified:	16 Nov 2012 12:07
URI:	http://eprints.lincoln.ac.uk/id/eprint/6846

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