Investigating RGS proteins in yeast

Hill, Claire and Goddard, Alan and Davey, John and Ladds, Graham (2006) Investigating RGS proteins in yeast. Seminars in Cell and Developmental Biology, 17 (3). pp. 352-362. ISSN 1084-9521

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Official URL: http://dx.doi.org/10.1016/j.semcdb.2006.03.008

Abstract

Regulator of G protein signalling (RGS) proteins are vital in the adaptation of cells to stimulation via G protein-coupled receptors. Yeast have been integral in elucidating the important role that RGS proteins play within cellular processes. In addition to extensive characterisation of the endogenous RGS proteins, these organisms have enabled the identification and analysis of numerous mammalian homologues. The simplicity and plasticity of the yeast pheromone-response pathway has facilitated studies which would have been impossible in mammalian systems and it is certain that yeast will continue to have a great impact on this field of research in the future.

Item Type:Article
Additional Information:Regulator of G protein signalling (RGS) proteins are vital in the adaptation of cells to stimulation via G protein-coupled receptors. Yeast have been integral in elucidating the important role that RGS proteins play within cellular processes. In addition to extensive characterisation of the endogenous RGS proteins, these organisms have enabled the identification and analysis of numerous mammalian homologues. The simplicity and plasticity of the yeast pheromone-response pathway has facilitated studies which would have been impossible in mammalian systems and it is certain that yeast will continue to have a great impact on this field of research in the future.
Keywords:GAP, RGS, SST2, Yeast
Subjects:C Biological Sciences > C700 Molecular Biology, Biophysics and Biochemistry
Divisions:College of Science > School of Life Sciences
ID Code:6827
Deposited By: Alan Goddard
Deposited On:15 Nov 2012 21:04
Last Modified:15 Nov 2012 21:04

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