Casettari, Luca and Vllasaliu, Driton and Castagnino, Enzo and Stolnik, Snjezana and Howdle, Steven and Illum, Lisbeth (2012) PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications. Progress in Polymer Science, 37 (5). pp. 659-685. ISSN 0079-6700

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Abstract

This review sets out to describe and discuss the synthetic approaches and the fields of application of PEGylated chitosan copolymers especially for medical use. The PEGylation of chitosan and chitosan derivatives is able to add new physicochemical properties to the cationic polysaccharide polymers, thereby overcoming some limitations, especially regarding their solubility and their use in drug and gene delivery (DNA and siRNA). All methods of derivatization have been considered and described together with the different methods of characterization of the copolymers. The capacities of PEGylated chitosan to reduce chitosan toxicity, to enhance membrane permeation and to form thermosensitive hydrogels have also been discussed.

Item Type:	Article
Keywords:	Absorption enhancement, Chitosan, Drug delivery, Gene delivery, PEG-g-chitosan, PEGylation
Subjects:	B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:	College of Sciences > Faculty of Science > Lincoln School of Pharmacy
Depositing User:	Driton Vllasaliu
Date Deposited:	14 Nov 2012 21:24
Last Modified:	14 Mar 2013 15:39
URI:	http://eprints.lincoln.ac.uk/id/eprint/6818

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