Chitinase inhibition by chitobiose and chitotriose thiazolines

Macdonald, James M. and Tarling, Chris A. and Taylor, Edward J. and Dennis, Rebecca J. and Myers, David S. and Knapp, Spencer and Davies, Gideon J. and Withers, Stephen G. (2010) Chitinase inhibition by chitobiose and chitotriose thiazolines. Angewandte Chemie, 49 (14). pp. 2599-2602. ISSN 0044-8249

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A good imitation: Di- and trisaccharide analogues of the oxazoline intermediate formed during enzymatic hydrolysis of chitin were found to be potent inhibitors of chitinase A. The high affinity and enzymatic stability of a readily synthesized thioamide trisaccharide (two molecules of which are shown in the enzyme active site), and the mechanism-based mode of inhibition, make this analogue a promising candidate for broad-spectrum chitinase inhibition.

Keywords:carbohydrates;enzyme inhibitors;fungicides;insecticides;thiazolines
Subjects:C Biological Sciences > C790 Molecular Biology, Biophysics and Biochemistry not elsewhere classified
Divisions:College of Science > School of Life Sciences
ID Code:6121
Deposited On:07 Sep 2012 21:14

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