Macdonald, James M. and Tarling, Chris A. and Taylor, Edward J. and Dennis, Rebecca J. and Myers, David S. and Knapp, Spencer and Davies, Gideon J. and Withers, Stephen G. (2010) Chitinase inhibition by chitobiose and chitotriose thiazolines. Angewandte Chemie, 49 (14). pp. 2599-2602. ISSN 0044-8249

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Abstract

A good imitation: Di- and trisaccharide analogues of the oxazoline intermediate formed during enzymatic hydrolysis of chitin were found to be potent inhibitors of chitinase A. The high affinity and enzymatic stability of a readily synthesized thioamide trisaccharide (two molecules of which are shown in the enzyme active site), and the mechanism-based mode of inhibition, make this analogue a promising candidate for broad-spectrum chitinase inhibition.

Item Type:	Article
Keywords:	carbohydrates;enzyme inhibitors;fungicides;insecticides;thiazolines, ref03, refdoi
Subjects:	C Biological Sciences > C790 Molecular Biology, Biophysics and Biochemistry not elsewhere classified
Divisions:	College of Sciences > Faculty of Science > School of Life Sciences
Depositing User:	Edward Taylor
Date Deposited:	07 Sep 2012 21:14
Last Modified:	03 May 2013 12:30
URI:	http://eprints.lincoln.ac.uk/id/eprint/6121

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