Oxidative stress and intraerythrocytic concentrations of sodium and potassium in diabetic dogs

Chansaisakorn, Winai and Sriphavatsarakom, Prarom and Sopakdittapong, Pisit and Trisiriroj, Monkon and Pondeenana, Somchai and Buranakarl, Chollada (2009) Oxidative stress and intraerythrocytic concentrations of sodium and potassium in diabetic dogs. Veterinary Research Communications, 33 (1). pp. 67-75. ISSN 0165-7380

Full content URL: http://link.springer.com/article/10.1007/s11259-00...

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Abstract

Oxidative stress parameters; thiobarbituric acid reaction substances (RBC-TBARS), catalase (RBC-CAT) and reduced glutathione (RBC-GSH)) and the intraerythrocytic concentrations of electrolytes; sodium and potassium (RBC-Na and RBC-K) were determined in 18 well- controlled (WC) and 22 poorly-controlled diabetic mellitus (DM). Dogs with DM had significant higher blood glucose concentration (P < 0.001), haemoglobin A1c (P < 0.01) and fructosamine (P < 0.001) compared to normal healthy dogs (n = 19). Diabetic dogs in both groups had higher RBC-CAT (P < 0.05) while RBC-TBARS were higher significantly only in poorly-controlled DM group (P < 0.05). The RBC-K was significantly higher in both DM groups (P < 0.001). No changes in RBC-GSH and RBC-Na were found between DM and control healthy dogs. By linear regression analysis, the relationship were found between degree of diabetic mellitus and RBC-CAT, RBC-TBARS, RBC-Na and RBC-K. The relationship was also found between oxidative stress parameters and intraerythrocytic K+. The results suggest that in diabetic dogs, oxidative stress occurs which related to the severity of disease and may affect potassium homeostasis.

Keywords:Oxidative stress, Intraerythrocytic sodium and potassium, Diabetic dogs
Subjects:C Biological Sciences > C742 Veterinary Biochemistry
Divisions:College of Science > School of Life Sciences
ID Code:5966
Deposited On:19 Aug 2014 08:50

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