1H NMR study of cerebral development in the rat

Bates, T. E. and Williams, S. R. and Gadian, D. G. and Bell, J. D. and Small, R. K. and Iles, R. A. (1989) 1H NMR study of cerebral development in the rat. NMR in biomedicine, 2 (5-6). pp. 225-229. ISSN 0952-3480

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Full text URL: http://dx.doi.org/10.1002/nbm.1940020509

Abstract

1H NMR spectroscopy of brain extracts was used to investigate the metabolic changes that take place during development of the neonatal rat brain. Data were obtained over the range 1-21 days. The concentration of N-acetylaspartate rose by a factor of 9 during this period, the most rapid rise occurring after day 9. The total creatine concentration rose from days 1-21, with a large increase between days 1 and 5. Taurine concentration rose until day 5, then fell from days 5-21. The concentration of choline-containing compounds fell during the 21 day period. The results are discussed in relation to brain development and conventional biochemical data. A major conclusion in relation to spectroscopy of children is that interpretation of changes seen in disease will require adequate data from age-matched controls.

Item Type:Article
Additional Information:1H NMR spectroscopy of brain extracts was used to investigate the metabolic changes that take place during development of the neonatal rat brain. Data were obtained over the range 1-21 days. The concentration of N-acetylaspartate rose by a factor of 9 during this period, the most rapid rise occurring after day 9. The total creatine concentration rose from days 1-21, with a large increase between days 1 and 5. Taurine concentration rose until day 5, then fell from days 5-21. The concentration of choline-containing compounds fell during the 21 day period. The results are discussed in relation to brain development and conventional biochemical data. A major conclusion in relation to spectroscopy of children is that interpretation of changes seen in disease will require adequate data from age-matched controls.
Keywords:1H, proton, NMR Spectroscopy, N-Acetylaspartate, Taurine, Brain, Development
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
C Biological Sciences > C141 Developmental Biology
Divisions:College of Science > School of Life Sciences
ID Code:5389
Deposited By: Timothy Bates
Deposited On:16 May 2012 15:58
Last Modified:16 May 2012 15:58

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